Developmental Circuits in Aging

Country: Greece

City: Heraklion

Abstr. due: 19.04.2015

Dates: 25.05.15 — 28.05.15

Area Of Sciences: Biology; Medicine;

Organizing comittee e-mail:

Organizers: EMBO


Development and the process of ageing are intimately linked through a number of remarkably conserved processes, including growth, regeneration or senescence. Such biological processes may be beneficial during development and young age but become detrimental with aging. In this EMBO workshop, we will cover the most up-to-date advances on developmental mechanisms and their impact on ageing. The Program covers several exciting topics, including stem cell function and longevity, epigenetic and metabolic changes during development and aging, immune regulators of development and health-span, senescence in the developing embryo, as well as DNA repair mechanisms and their functional role in development and disease.

Connecting the fundamental process of development with ageing is conceptually novel and the recent intellectual advances are rapidly evolving. Single genes or pathways that are known to determine longevity also play a prominent role during development. The concept of antagonistic pleiotropy also suggests that a number of gene circuits limiting lifespan or promoting age-related diseases have been primarily selected for being beneficial during development and young age. Thus, the molecular mechanisms governing cell fate at early and late stages in life are intimately linked and widespread across the animal kingdom.

Topics to be covered at the workshop include:

  • Stem cells and longevity
  • DNA damage and Aging
  • Regeneration and Senescence
  • Epigenetic mechanisms in Aging and Cancer
  • Metabolic homeostasis and Aging

Conference Web-Site: