HIV and Co-Infections: Pathogenesis, Inflammation and Persistence

Country: Canada

City: Whistler

Abstr. due: 11.01.2018

Dates: 15.04.18 — 19.04.18

Area Of Sciences: Biology;

Organizing comittee e-mail: info@keystonesymposia.org

Organizers: Keystone Symposia

 

Better understanding of HIV pathogenesis is the cornerstone for advances in HIV prevention and vaccine design, long-term therapies and strategies for remission or eradication. Despite remarkable progress in the care of HIV-infected individuals and successful conversion of HIV into a chronic disease, gaps in knowledge regarding the mechanisms of evasion of immune responses, establishment of latency and persistence, pathways involved in chronic inflammation and the potential role of co-infections persist and hamper the design of targeted interventions. This meeting aims to: 1) Deepen understanding the mechanisms of establishment and maintenance of HIV reservoirs including viral evolution on ART, epigenetic regulations and metabolic states; 2) Provide updates on innovative strategies for HIV remission and control; 3) Determine the role of TB and other co-infections in inflammation and establishment of HIV viral reservoirs; and 4) Explore the pathways that induce chronic inflammation and the molecular interplays between inflammation and viral reservoirs in chronic HIV infection. The conference is novel because it is being paired with Keystone Symposia’s conference on “Tuberculosis: Translating Scientific Findings for Clinical and Public Health Impact.” Of the estimated 34 million people living with HIV in the world today, more than a third are also infected with Mycobacterium tuberculosis. Important questions related to HIV pathogenesis including pathways of inflammation and establishment of reservoirs may be greatly influenced by TB and other co-infections. Inflammation and viral persistence are likely fueled by each other, which provides a rationale for addressing these two topics in the same conference. In addition, the meeting’s joint pairing with one dedicated to TB should facilitate interdisciplinary interactions and highlight the importance of TB in HIV pathogenesis and vice versa.

Conference Web-Site: http://www.keystonesymposia.org/index.cfm?e=Web.Meeting.Summary&meetingid=1560&subTab=summary