Postdoc in Chemical Synthesis of Switchable Peptide-based Nanopores

Country: Sweden;

City: Göteborg

Vacancy added: 22.01.2019

Employer: University of Gothenburg

Vacancy type: PostDoc vacancy;

Resumes due: 17.03.2019

 

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

We are seeking a highly motivated and talented person for chemical synthesis of switchable peptide-based nanopores. The basic principle of a modified nanopore is to detect chemical or physical properties transducing them through a microelectronic device into electrical signals. Therefore, such pores a highly suitable to be incorporated into miniaturized electronic components for biomedical or analytical applications. In living organisms, the transport of ions is performed by ion channels and transporters. Basic principles of the working mechanism and the reason for their efficiency/high selectivity are well understood to date. However, their functionality is only provided in mechanical instable lipid membranes. Synthetic nanopores are mainly based on silica materials or organic polymers and were demonstrated to be useful as sensory devices for analytical applications. Unfortunately, their sensitivity and selectivity are much lower than for biological pores. Thus, the combination of biological and synthetic nanopores as a hybrid pore system should overcome current limitations of conventional pore systems. Therefore, the major objective of this project is to engineer hybrid systems based on functional peptides attached to a carrier (e.g. polymer nanopore). 

Methods

  • Solid phase peptide synthesis
  • Liquid-phase synthesis (Organic chemistry)
  • Conjugation techniques
  • Analytical and preparative HPLC, Mass spectrometry (ESI and MALDI TOF)
  • CD and NMR spectroscopy
  • Fluorescence microscopy

The candidate will be part of a newly established Wallenberg Centre for Molecular and Translational Medicine in Gothenburg.

Subject area

Engineering and chemical synthesis of hybrid systems based on functional peptides and their attachment to an artificial support.

Job assignments

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance. The applicant must have a PhD degree and is expected to have a strong record of scientific productivity with publications in internationally renowned journals. The applicant must have an extensive background in organic chemistry/peptide chemistry and experience in conjugation techniques, engineering of hybrid systems. Experience in fluorescence microscopy is beneficial. The successful applicant is expected to plan, execute and analyse experiments in an independent manner and to actively contribute scientifically to the group. Candidates must have excellent oral and written communication skills in English.

The candidate will synthesize functional peptides and perform their attachment to a solid carrier developing novel functional materials using de novo hybrid system design, SPPS, conjugation techniques (click chemistry) including purification (HPLC), mass spectrometric and fluorescence microscopic characterization.

Qualifications

To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject.

Employment

Type of employment: Fixed-term employment, 2 years 
Extent: 100 % 
Location: Department of Chemistry and Molecular Biology, Gothenburg
First day of employment: As soon as possible or as agreed

Appointment procedure

Please apply online

The application shall include:
Cover letter with an explanation of why you apply for the position

CV including scientific publications
Copy of exam certificate 
Two references (name, telephone no, relation)

For further information regarding the position

Regarding the position please contact:
Alesia A. Tietze, Associate Senior Lecturer, a.tietze@tietze-lab.com

Regarding the appointment procedure, please contac:
Ann Svensson, Human Resources Officer, +46 (0) 31-786 2558, ann.svensson@cmb.gu.se

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date: 2019-02-17

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned. 

 
Where to send resume: