Postdoctoral Researcher Mutagenesis in human liver through innovative 3D hepatocyte cultures

Country: France;

City: Rennes

Vacancy added: 26.04.2019

Employer: Irset

Resumes due: 15.06.2019



The Irset team “Dynamics of Microenvironment and Cancer - Structure, Signaling, Contaminants” (Dymec) opens a position available for a highly motivated postdoctoral toxicologist.


Under the supervision of Dr. Sophie Langouët, the postdoctoral researcher will implement the project 3D-IVMA, a 3-year funded by ITMO Cancer/Aviesan (France). This project aims to develop and integrate of new innovative in vitro 3D culture approaches for hepato-Mutagenesis Assessment. The researcher is expected to actively participate in the experiments, do a systematic review of the literature, data management and analysis, writing scientific papers. A strong cellular and molecular toxicology background in required.

Main Activities

  • Research activities using various technical approaches (cell cultures of human hepatocytes (primary and transformed in 2D and 3D), xenobiotic metabolism activities analysis, DNA damages characterizations, mutations analysis) and all experiments required for the project.
  • Interpreting and discussion of the results with other project members.
  • Scientific communication activities including the drafting of articles, and presentations at conferences.
  • Systematic reviews of the literature.

Associated Activities

  • Collaboration with other Irset teams as well as Institut Pasteur of Lille (France).
  •  Mentoring of master researchers.


The candidate should have preferentially a PhD in Toxicology with good knowledge in carcinogenesis and DNA damages (cell biology specialist could also fit with the profile). Experience in cell culture, xenobiotic metabolism, genotoxicity and mutation analysis is required. A first experience as a postdoctoral fellow and outstanding research achievements are an asset.


  • Skills in cell culture, enzymes activity measurements, mutations analysis and (geno)toxicology techniques required for the project
  • Excellent organization and communication skills.
  •  Excellent writing skills.


  • Team player, yet capable of working autonomously
  • Scientific independence
  • Written and spoken competence in English is required

Specificity(ies) / Constraint(s)

Full-time position at Irset in Rennes, Brittany (Rennes 1 University Health Campus)

Requested Experience

  • Experience cellular and molecular toxicology
  • Strong experience in cell culture is an asset, as well as genotoxicology knowledge

Requested Qualification

  • PhD in toxicology, cell biology, cancer or related disciplines

Unit Name

Irset - Institut de recherche en santé, environnement et travail | Research Institute for Environmental and Occupational Health

Unit Director

Bernard Jégou

Unit Composition

Nearly 300 persons
10 research teams incl. 1 Avenir-Inserm team, and 2 certified technology platforms.


9 avenue du Prof. Léon Bernard |35000 RENNES -



Fixed-term contract (CDD)


1 year, renewable up to 3


According to experience

Requested Start Date

September 1, 2019


Please email your detailed CV, including a list of your published papers, a letter of intent explaining your motivations for the chosen position, and contact details of three referees to Dr. Sophie Langouet ( indicating “Postdoc Hiring” as subject.

Deadline for application: June 15th 2019.

Contact: Dr Sophie Langouet | +33 (0)2 23 23 48 06

Where to send resume: