Postdoctoral Position in Molecular Immunology (KU Leuven, Belgium)

Country: Belgium;

City: Leuven

Vacancy added: 09.07.2019

Employer: KU Leuven

Resumes due: 31.07.2019

 

The host lab: The Adaptive Immunity laboratory at KU Leuven is looking to extend its team with a talented and motivated postdoctoral scientist. The international group led by Prof Susan Schlenner has two main study areas: • To understand the regulatory mechanisms of Treg lineage stability/plasticity using an holistic, in vivo approach in order to understand stability/plasticity-determining molecular networks at epigenetic/transcriptional/proteomic levels. We are using new mouse models to gain an insight of unprecedented depth into the molecular switches that determine a Tregs’ fate. This knowledge is invaluable to preclinical studies that aim at regulating Treg suppressive activity or Treg numbers in inflammatory diseases or cancer. • To study the role of epitranscriptomic regulation in the murine immune system we have generated a number of novel mouse strains. The impact of epitranscriptomic modulation of immune cell development, homeostasis and activity is at its infancy and we are taking first important steps in deciphering the regulatory role of transcript modifications. The lab has strong expertise in Crispr/Cas, mutant mice generation and flow cytometry, as well as a strong focus on in vivo work. We are heading the genome engineering platform and the FACS core facility. Furthermore, we have implemented single cell RNAseq and alternatives of it (PsiSeq/PerturbSeq), and have excellent expertise on molecular techniques such as cloning. In our laboratory we nurture an environment of collaboration and support, trying to provide every lab member with the best of opportunities to follow their ambitions within the lab as well as their career ambitions. The host institution: KU Leuven is Belgiums leading university and is continuously in the top 10 of the worlds’ most innovative universities. Core facilities with highest quality of service include the genomics core, the molecular small animal imaging centre (MoSAIC), MutaMouse (genome engineering service), cell imaging core (CIC), animal facility, microscopy core, electron microscopy, FACS core, mass spectrometry center, phosphoproteomics analysies, and many more. In this very collaborative environment, special equipment such as ultracentrifuges, Seahorse Extracellular Flux Analyzer, Typhoon Biomolecular Imaging and many more are shared across departments.

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Responsibilities

Responsibilities:

Your main focus will be an independent and fully funded project that aims at dissecting the molecular networks which underlie the stability of Treg as well as their plasticity. Mouse models are in development for you to kick-start. This project requires the handling of mice, lentiviral work, epigenetic and transcriptional analyses, and bioinformatic analyses.

Beyond that, you are invited to collaborate with your colleagues on projects such as the role of the epitranscriptome in T cells.

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Please feel encouraged to apply for this positionif at least three of the below listed aspects apply to you:

  • Adaptive Immunology background (such as you did your PhD in Immunology)
  • Repertoire of molecular techniques (such as cloning and qPCR) and cellular assays (such as on ex vivo cells)
  • Solid knowledge on multi-color flow cytometry
  • Basic or advanced knowledge on bioinformatics (such as RNAseq, IPA, R programming)
  • Experience in working with mice / in mouse models
  • Your CV is competitive for a postdoctoral fellowship application (at least one first author paper in past 2 years in a peer-reviewed journal).

Offer

We offer:

A three-year position to start as soon as possible (appointment for an initial period of 1 year, renewable depending on performance) in our international team to work on an exciting project in which we will aim to go significantly beyond the state-of-the-art. We offer support to submit a postdoctoral fellowship application.

Please submit the following documents:

  • Motivation letter (including your research interest and a summary of your previous research experience)
  • CV (including list of techniques that you are proficient in, ResearcherID or OrchID)
  • Names of 2-3 referees

Interested?

Additional information about the vacancy can be obtained from: susan.schlenner@kuleuven.be.

We look forward to your application!

You can apply for this job no later than July 31, 2019 via the online application tool

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

 
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