Mitochondria, Metabolism and Heart Failure

Страна: США

Город: Santa Fe

Тезисы до: 01.10.2014

Даты: 27.01.15 — 01.02.15

Область наук: Биологические;

Е-мейл Оргкомитета:

Организаторы: Bayer HealthCare Pharmaceuticals and Takeda Pharmaceutical Company Limited


The objectives of this meeting are: 1) To mechanistically connect the fundamental biology of metabolism and mitochondrial function with the pathogenesis of heart failure, a major cause of morbidity and mortality in the world; and 2) To increase basic understanding of metabolism and mitochondrial function using observations in cardiac muscle, a traditional platform for these studies. The ongoing convergence of the cardiac metabolism and mitochondrial biology fields provides a particularly cogent rationale for a meeting with this focus. Moreover, large gaps of knowledge exist in this area such as the precise molecular signaling that connects metabolism and energy sensing with mitochondrial function, and the roles of basic mitochondrial processes (e.g. biogenesis, fission, fusion, mitophagy, maintenance of mitochondrial genome integrity) in metabolism and heart failure. These deficiencies in fundamentally important scientific knowledge and their clinical implications for a common and lethal disease confer exceptional significance on the proposed meeting. Although a number of cardiac research meetings take place each year, most are of a very general nature or so specialized that they examine only a single process in isolation. A major innovation of the proposed meeting is its ability to examine metabolism, mitochondrial function, and heart failure in an integrated context and in the depth required to critically examine existing paradigms. A second significant innovation is to have the meeting run concurrently with one on Diabetes and Metabolic Dysfunction. This opportunity has been exploited by designing three of the morning sessions to be joint between the two meetings.

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