Special Issue of International Journal of Molecular Sciences "Reverse Vaccinology"

Страна: N/A

Город: N/A

Тезисы до: 31.12.2016

Даты: 31.12.16 — 31.12.16

Область наук: Биологические;

Е-мейл Оргкомитета: http://www.mdpi.com/journal/ijms/special_issues/reverse_vaccinology

Организаторы: International Journal of Molecular Sciences


This call for papers is focused on the rapidly expanding field of Reverse Vaccinology (RV) and Structural Vaccinology (SV). RV initially uses bioinformatics approaches to identify vaccine candidates in the protein coding genome (proteome) of pathogens, and more recently, of tumors. With respect to pathogens, there is a resurgence of interest in all aspects of vaccinology, including RV, in order to combat mounting antibiotic resistance. RV has already led to the development of a subunit vaccine against Neisseria meningitidis serogroup B (i.e., Bexsero). With respect to cancer, recent advancements in RV suggest that personalized vaccines can be developed to recognize mutations that result in protein coding changes specific to the tumour. SV is a logical extension of an RV approach and aims to re-design protective antigens to increase protective efficacy and stability, and thus enhance formulation and delivery of subunit vaccines. These renewed foci have coincided with the advent of “Big Data” and our increasing ability to apply bioinformatics approaches to interpret the vast amounts of data that are being generated.

This Special Issue aims to bring together all branches of the RV research community and is soliciting manuscripts pertaining to original research, mini and full reviews, short communications, as well as perspectives, which address any aspect of RV. This Special Issue will incorporate RV research pertaining to bacterial, eukaryotic and viral pathogens, as well as immunotherapy approaches to cancer, and all types of vaccine design (e.g., subunit or epitope). Submissions are invited that include, but are not limited to:

    In silico approaches to identifying vaccine candidates
    Bioinformatic tools and databases for conducting RV research
    Confirmation of candidates identified by RV in animal models or other immunogenicity assays
    Clinical trials of vaccines incorporating antigens identified from an RV approach
    Updates on the use of RV derived vaccines in clinical practice (e.g., Bexsero)
    Structural vaccinology approaches to enhance efficacy, stability and delivery of protective antigens.


Веб-сайт конференции: http://www.mdpi.com/journal/ijms/special_issues/reverse_vaccinology