Synthesis of composite materials (polymer hydrogels) for medicine purposes

Microphotographs of two types of hybrid materials obtained using scanning electron microscopy. Formation of silica components in composites (A) through the sol-gel process and (B) using fumed nanosilica A300 composed of nanoparticles (8-12 nm in diameter) forming  aggregates (< 1000 nm) and agglomerates of aggregates (> 1000 nm) . Different morphologies of silicas affect not only structure of composites, but also a drug release rate.

Composites based on nano-structured fumed silica-polymers systems are widely used for various purposes, e.g. as drug delivery systems in medicine. Control of bioactive substance release can be achieved by varying the composition and structure of the composites to maintain an optimal concentration during patient treatment. One possible use of these systems is in anesthesia. Nanocomposites can act as absorbents of toxins that allows us to use them to improve patient's condition and reduce the time of recovery.

The properties of composites depend on types of nanosilicas and polymers (polyvinyl alcohol, polyacrylic acid, chitosan, etc.) with controlled degrees of polymerization and crosslinking. Certain bioactive compounds can be proposed as the solutions to specific practical problems, such as in the treatment of child or adult trauma.

The composites are based on multifunctional biocompatible polymer hydrogels. In compare with biopolymers, they are more stable and have a simpler structure, both of which provide reproducible properties of immobilized drugs and their controlled release.

Developers:

The Institute of General and Inorganic Chemistry, Department of Composite Materials, Laboratory of Polymer-Containing Disperse Systems ( Republic of Belarus )

Chuiko Institute of Surface Chemistry

Contacts: 
Minsk, Belarus: 9/1 Surganov Street, Minsk BY-220072, Tel: (+375) 17 332 16 40; Kyiv, Ukraine: http://www.isc.gov.ua/index.php/en/; Phone: +38 (044) 422-96-04; Fax: +38(044) 424-35-67; e-mail: payentkovv@gmail.com