Forty Years of mRNA Splicing: From Discovery to Therapeutics

Страна: США

Город: Cold Spring Harbor

Тезисы до: 30.09.2017

Даты: 22.10.17 — 25.10.17

Область наук: Биологические;

Е-мейл Оргкомитета:

Организаторы: Cold Spring Harbor Laboratory


The discovery of mRNA splicing in 1977 established a new step in the central dogma of molecular biology, the “flow” of genetic information from DNA to RNA to protein product. Our meeting will focus on forty years of advances in this field with topics such as the spliceosome, alternative RNA splicing, diseases related to RNA splicing and therapeutics focused on RNA splicing. The meeting will encompass discussions not only of what has already been accomplished, but also how this history continues to shape the future.  
This meeting will be the seventh in a series organized by the CSHL Meeting and Courses Department together with Genentech Center for the History of Molecular Biology and Biotechnology. We have invited speakers who made many of the seminal discoveries that began the field, as well as those who are working in the field now. Like the previous meetings in the series, this meeting will provide an excellent opportunity to look in depth at a topic and to share the stories that are often missing from academic accounts.

The meeting will be held in Grace Auditorium at Cold Spring Harbor commencing 1:00 pm on Sunday, October 22, and finish Tuesday after dinner, with departures the following morning, October 25, after breakfast.


Themes include:

  • History and Overview
  • Biology of Spliceosome
  • Introns, Exons and Alternative splicing
  • Spliceosome Complexes
  • Diseases of mRNA splicing
  • Therapeutic approaches to mRNA Splicing diseases

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