Cryo-EM from Cells to Molecules: Multi-Scale Visualization of Biological Systems

Страна: США

Город: Tahoe City

Тезисы до: 07.11.2017

Даты: 04.02.18 — 08.02.18

Область наук: Биологические;

Е-мейл Оргкомитета:

Организаторы: Keystone Symposia


Fast-evolving cryo-EM visualization techniques have recently started to illuminate the inner workings of complicated and dynamic biological assemblies with a level of detail we have never seen before. Cryo-EM is now the state-of-the-art methodology for taking snapshots of biological systems from low to high resolution and with various levels of complexities, from small macromolecular complexes all the way to subcellular organizations. This symposium will showcase cryo-EM breakthroughs in addressing crucial problems in cell biology and will further highlight cryo-EM imaging as a platform for the integration of data from orthogonal approaches. With talks on a variety of biological specimens, procedures and types of biological questions, the meeting aims to attract a very diverse audience from both academia and industry with interest in the method, and beyond the traditional cryo-EM specialist. The symposium will focus on four themes: 1) Single-particle cryo-EM with attention to the characterization of the conformational ensemble adopted by macromolecular complexes and aiming to delineate their mechanism of action; 2) Cryo-electron tomography (cryo-ET) and correlative light electron microscopy (CLEM) to visualize cellular organizations and their dynamics; 3) The emergence of cryo-EM as tool for drug discovery and translational research through both high-resolution structure determination and characterization of cellular phenotypes; and 4) Recent developments in sample preparation and image acquisition. Furthermore, the symposium will include workshops in specimen preparation and evaluation of suitability for cryo-EM, modeling of structures using cryo-EM data, and how to set up a cryo-EM lab.

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