Protein Homeostasis in Health and Disease 2020 Conference

Страна: США

Город: Cold Spring Harbor

Тезисы до: 31.01.2020

Даты: 21.04.20 — 25.04.20

Область наук: Биологические;

Е-мейл Оргкомитета:

Организаторы: Cold Spring Harbor Laboratory; Judith Frydman, Stanford University F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany Richard Morimoto, Northwestern University


Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.

You are invited to participate in the 2020 meeting on Protein Homeostasis in Health & Disease. Groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting over the past three decades. The 2020 meeting provides an opportunity to showcase the latest research in this area and will feature talks by leading investigators.

The meeting will begin after dinner at 7:30 p.m. on Tuesday, April 21, and conclude with lunch on Saturday, April 25, 2020.

Session Chairs & Invited Speakers:


Integrative Stress Signaling in Aging and Disease

Chairperson: Jonathan Weissman, University of California, San Francisco
Keith Blackwell, Harvard Medical School
Ursula Jakob, University of Michigan Medical School

Chaperone Mechanisms I

Chairperson: F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Elke Deuerling, University of Konstanz, Germany
Lila Gierasch, University of Massachusetts, Amherst

Protein Aggregation in Aging and Neurodegenerative Diseases

Chairperson: Rick Morimoto, Northwestern University
Sheena Radford, University of Leeds, UK

Stress Granules and Phase Transitions

Chairperson: Simon Alberti, Max Planck Institute of Molecular Cell Biology, Germany
Manajit Hayer-Hartl, Max Planck Institute, Martinsried, Germany

Chaperone Mechanisms II

Chairperson: Judith Frydman, Stanford University
Rachel Klevit, University of Washington

Clearance Mechanisms

Chairperson: Ivan Dikic, Goethe University Frankfurt, Germany
Daniel Finley, Harvard Medical School
Dan Southworth, University of California, San Francisco

Organellar Proteostasis and Spatial Quality Control

Chairperson: Peter Walter, University of California, San Francisco
Thomas Langer, University of Cologne, Germany
David Ron, University of Cambridge

Correcting Proteostasis in Aging and Disease

Chairperson: Gergely Lukacs, McGill University
Jeff Kelly, The Scripps Research Institute

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