PhD Fellow within Metabolomics of Marine Microorganisms [closing 25.10.20]

Страна: Норвегия;

Город: Tromsø

Добавлена: 01.10.2020

Работодатель: The Faculty of Biosciences, Fisheries and Economics (BFE) consists of Department of Arctic and Marine Biology, Norwegian College of Fishery Science (NFH) and School of Business and Economics

Тип: PhD position;

Для кого: For researchers;

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Дедлайн подачи: 25.10.2020

 

The position of Research Fellow is a fixed term position for a period of 4 years. The nominal length of the PhD program is three years. The fourth year is distrubuted as 25 % each year, and will consist of teaching and other duties for the Faculty of Biosciences, Fisheries and Economics. The main objective of the appointment as a Research Fellow is to qualify for work in a senior academic position. No one may be appointed to more than one fixed term period as a Research Fellow at the same institution.

Marbio is an analytical platform for natural products at UiT. The expertise at Marbio involves diversity and ecology of marine fungi and bioassay-guided purification to isolate active compounds of Arctic marine organisms to be included in a library of natural products. Arctic and sub-Arctic marine organisms are explored, searching for compounds with activities against bacteria, cancer and diabetes as well as compounds with immune-modulatory and antioxidative effects. Marbio’s screening campaign is based on a classic bioassay-guided fractionation approach supplemented with genome-based approaches.

The research group for natural products and medicinal chemistry at the Department of Pharmacy has infrastructure and competence related to characterization of bioactive natural products. The research group has extensive experience in using metabolomics as a tool for identifying biomarkers in complex samples.

CANS is a large strategic interdisciplinary centre at UiT - the Arctic University of Norway for research, education, innovation and dissemination related to antimicrobial resistance (AMR). CANS currently involves fourteen research groups located at three faculties and covers topics within marine bioprospecting - identification and characterization of new antibacterial activities, design and synthesis of new antibiotics and resistance inhibitors, the evolution and molecular epidemiology of AMR, host-microbe-drug interactions as well as antibiotic stewardship.

The centre aims to strengthen current activities, but also support new basic research in novel concepts for sustainable antibacterial activities in AMR-prevention and treatment strategies through new permanent positions.

The workplace is at UiT in Tromsø. You must be able to start in the position within a reasonable time, within 6 months after receiving the offer.

The objective of the position is to complete research training to the level of a doctoral degree. Admission to a PhD programme is a prerequisite for employment, and the programme period starts on commencement of the position. The PhD candidate shall participate in the faculty’s organized research training, and the PhD project shall be completed during the period of employment. Information about the application process for admission to the PhD programme, application form and regulations for the degree of Philosophiae Doctor
(PhD) are available here.

The project/ The position's field of research

The successful candidate should do basic research in the field of mass spectrometry-based metabolomics of marine microorganisms. Different types of mass filters will be used to generate the metabolite profiles in order to evaluate what kind of workflow is best suited to identify secondary metabolites in complex extracts. Different solutions for processing data will also be tested in the project. Selected compounds will be isolated using mass guided fractionation on semi-preparative HPLC, and the isolated compounds will be structurally characterized and tested for biological activity against human pathogenic bacteria. The bioactivity testing will be done both in Marbio and in cooperation with other research groups associated with CANS.

The candidate will have direct access to state-of-the-art laboratory facilities at Marbio and the research group for natural products and medicinal chemistry, including high-resolution mass spectrometry (TOF and Orbitrap) and ion mobility spectrometry in combination with HPLC/UHPLC.

The candidate will be engaged in:

  • Optimizing methods for analysis of microbial extracts on UHPLC-HR-MS
  • Statistical analysis of metabolomic data
  • Isolation of potential bioactive secondary metabolites
  • Structure elucidation of isolated compounds
 
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