Postdoc in Multimodal Optical Imaging for Colon Cancer Diagnosis [closing 01.11.20]

Страна: Дания;

Город: Lyngby

Добавлена: 25.10.2020

Работодатель: The Department of Health Technology at the Technical University of Denmark (DTU)

Тип: PostDoc vacancy;

Для кого: For researchers;

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Зарплата: https://www.dtu.dk/english/about/job-and-career/vacant-positions/job?id=4a4af992-da93-4508-9a31-6bd84d897177

Дедлайн подачи: 01.11.2020

 

The Department of Health Technology at the Technical University of Denmark (DTU) is seeking a candidate for a 1.5-year Postdoc position on Multimodal Optical Imaging for Colon Cancer Diagnosis.

The Postdoc will join the Biophotonic Imaging group at the Department of Health Technology (DTU Health Tech) consisting of ca 10 employees, including several PhD students and postdocs. Within the group, we are working on the advancement of optical imaging technologies for clinical and biological applications. Currently we have research projects on multimodal imaging combining optical coherence tomography, two-photon excitation fluorescence microscopy, lightsheet microscopy, fibre delivery of ultrashort pulses, as well as investigation of biomarkers relevant for cancer diagnosis using biophotonic imaging.

Background
Colorectal cancer is the second most common cause of cancer death in Europe, causing 225 000 deaths in 2012 (12% of the total).[1] Current standard practice for diagnosing colorectal cancer is white light endoscopy, during which the colonoscopist assesses the appearance of polyps and tissue to identify possible neoplastic changes and decides whether to resect for further analysis using histopathology. To avoid a high number of undetected early stages of colorectal cancer, this procedure results in many unnecessary resections, posing higher risk for colon perforation requiring emergency surgery. On top of this, colonoscopy is not as effective in prevention of colorectal cancer in the right colon as in the left and provides sensitivity and specificity levels starting at 60% and 40%.[2]

Therefore, a technology to assess the malignancy of suspect lesions in situ during colonoscopy would benefit both the patients and reduce healthcare costs. Optical imaging modalities can non-invasively probe tissue using non-ionizing radiation. This makes optical imaging an obvious choice for use as a diagnostic tool in many fields in healthcare, including oncology.

Responsibilities and tasks
Your aim will be to demonstrate that optical properties extracted from OCT images[3] can serve as a biomarker and improve diagnosis in a multimodal imaging setup.

Your work is part of the European project “PROSCOPE” (www.proscope-h2020.eu), funded by H2020, where we develop a classification tool for colon cancer diagnosis based on multimodal optical images in collaboration with European project partners. The project includes the following tasks, to which you will substantially contribute:

    measuring OCT data on test samples and tissue models using our existing OCT setups at DTU;
    adapting an existing model for the measured OCT signal, developed in our group, and using this model to extract the optical properties from the data;
    upgrading our research grade OCT systems to implement offset OCT to enhance imaging depth, in close collaboration with the group of Prof. Kishan Dholakia at the University of St. Andrews, Scotland (partner in PROSCOPE);
    combining your findings in a multimodal approach with multiphoton fluorescence and Raman spectroscopy images gathered on our microscopes, to show further improved accuracy;
    analysing the OCT data gathered from colon tissue samples, in close collaboration with the group of Dr. Angelika Unterhuber at the Medical University of Vienna, Austria.

You will also co-supervise a PhD student who is perfecting the tissue models and who will implement the Raman system in our lab and use it on those models.

 
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