Research Fellow in Structural Biology/cryo-EM [closing 06May2021]

Страна: Великобритания;

Город: Leeds

Добавлена: 12.04.2021

Работодатель: University of Leeds

Тип: PostDoc vacancy;

Для кого: For researchers;

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Дедлайн подачи: 06.05.2021

 

The 203 kDa b-Barrel Assembly Machinery (BAM) complex of Gram negative bacteria is an integral membrane protein that is required for the folding and insertion of outer membrane proteins (OMPs) and hence is essential for cell viability. Despite this central importance, how BAM folds and inserts the multitude of different OMP sequences that comprise the OM, and how this is able to occur efficiently in the crowded OM in the absence of an obvious source of energy such as ATP or a proton gradient, remain unclear. We are looking for an outstanding postdoctoral research fellow to join an MRC-funded team investigating the mechanism of action of the BAM complex using biochemistry, biophysics and structural biology.

This post will use cryoEM and cryoET, backed up by biochemical and biophysical experiments, to probe the structure and of the BAM complex in different membrane environment and at different stages of its catalytic reaction cycle in OMP folding. Successful execution of this MRC-funded programme grant will thus result in a new molecular understanding of this fascinating complex that is vital for bacterial life.

 
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