Single-molecule bioscience with nanostructured photonic device. Physics PhD Studentship [closing 24May2021]

Страна: Великобритания;

Город: Exeter

Добавлена: 10.04.2021

Работодатель: The University of Exeter and the University of Queensland

Тип: PhD position;

Для кого: For researchers;

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Дедлайн подачи: 24.05.2021

 

The University of Exeter and the University of Queensland are seeking exceptional students to join a world-leading, cross-continental research team tackling major challenges facing the world’s population in global sustainability and wellbeing as part of the QUEX Institute. The joint PhD programme provides a fantastic opportunity for the most talented doctoral students to work closely with world-class research groups and benefit from the combined expertise and facilities offered at the two institutions, with a lead supervisor within each university. This prestigious programme provides full tuition fees, stipend, travel funds and research training support grants to the successful applicants.  The studentship provides funding for up to 42 months (3.5 years).

Eight generous, fully-funded studentships are available for the best applicants, four offered by the University of Exeter and four by the University of Queensland. This select group will spend at least one year at each University and will graduate with a joint degree from the University of Exeter and the University of Queensland.

Project Description

The detection of single-molecule processes and dynamics inside cells requires optical sensors of extraordinary sensitivity and that are miniature in size. This proposals seeks to develop a state of the art sensing approach based on silicon nanosensing structures that can be fabricated on chip and attached to the end of a fiber. The needle like sensor can be inserted into a single cell. In contact with the cell, they can interlaise them in their cytoplasm. By developing advanced optical techniques for reading out the sensor signals, we will develop the first single-cell single-molecule sensors that are label-free and operate on microsecond timescales. This will allow us to track dynamics process such as the conformational movements of enzymes,  and the contacts with specific proteins inside of cells that mediate biological signals. The colaboration between the Bowen (silicon nanochip sensors) and Vollmer (single-molecule sensing and cell analysis) will enable us to translate state-of-the art sensing techniques into a chip-scale platform that we use for fundamental studies of proteins structure, dynamics and folding, and for developing applications such as in vivo and single cell sensing in collaboration with Alan Rowan, who's the director of the AIBN in UQ.

 
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