Postdoctoral Fellowship in Immunology

Країна: Швеція;

Дедлайн: 15.09.2010



Postdoctoral Scholarship in Immunology, Stockholm University, Sweden

Job Description: The innate and the adaptive immune system are collaborating to prevent the entrance of microorganisms and to prevent the development of active disease. In the lungs, infected alveolar macrophages and dendritic cells have long been known as a primary site of M. tuberculosis infection. More recently, other cell types, such as adipocytes, fibroblasts, endothelial cells, and most interestingly, epithelial cells have also been identified as cellular niches for latent M. tuberculosis.

Upon infection, epithelial cells can release a panel of antimicrobial effector molecules, cytokines, and chemokines, which govern innate immune responses and initiate specific immunity. This complex network of mediators induces activation of antimicrobial activity in macrophages and perhaps other cell types, migration of antigen laden phagocytes to the draining lymph nodes, and finally the influx of antigen-specific T-lymphocytes to the site of infection.

Primary infection most often leads to the formation of a well organised granuloma consisting of central macrophages with surrounding lymphocytes and fibroblasts. This cellular microenvironment provides a physical and immunological barrier for the entrapped bacilli thereby preventing multiplication and spread of the mycobacteria. Live mycobacteria may also remain in many different cell types throughout the body and undergo a dormancy phase. Factors disrupting the fine-tuned balance between the low level mycobacterial metabolism and the cellular immune response of the host are likely to increase the risk of tipping the balance in favour of the pathogen and result in reactivation of disease.

In this project we aim to identify novel host genes involved in control of bacterial load, and regulation of inflammation and immune responses, and bacterial molecules involved in escape from such immune regulatory and effector mechanisms. The project is done in collaboraqtion with various international groups and is financed by the European Community. The project is done in mouse models.

The successful candidate is expected to be highly motivated and to have a strong theoretical background in immunology. An excellent command of English is required and experience with animal work, real time PcR, enzyme linked immunosorbent assays, in vitro culture of primary cells and cell lines and flow cytometry based analyses, will be considered strong merits.