Protein Homeostasis in Health and Disease 2020 Conference
Країна: США
Місто: Cold Spring Harbor
Тези до: 31.01.2020
Дати: 21.04.20 — 25.04.20
Область наук: Біологічні;
Е-мейл Оргкомітету: carr@cshl.edu
Організатори: Cold Spring Harbor Laboratory; Judith Frydman, Stanford University F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany Richard Morimoto, Northwestern University
Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.
You are invited to participate in the 2020 meeting on Protein Homeostasis in Health & Disease. Groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting over the past three decades. The 2020 meeting provides an opportunity to showcase the latest research in this area and will feature talks by leading investigators.
The meeting will begin after dinner at 7:30 p.m. on Tuesday, April 21, and conclude with lunch on Saturday, April 25, 2020.
Session Chairs & Invited Speakers:
Integrative Stress Signaling in Aging and Disease
Chairperson: Jonathan Weissman, University of California, San Francisco
Keith Blackwell, Harvard Medical School
Ursula Jakob, University of Michigan Medical School
Chaperone Mechanisms I
Chairperson: F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Elke Deuerling, University of Konstanz, Germany
Lila Gierasch, University of Massachusetts, Amherst
Protein Aggregation in Aging and Neurodegenerative Diseases
Chairperson: Rick Morimoto, Northwestern University
Sheena Radford, University of Leeds, UK
Stress Granules and Phase Transitions
Chairperson: Simon Alberti, Max Planck Institute of Molecular Cell Biology, Germany
Manajit Hayer-Hartl, Max Planck Institute, Martinsried, Germany
Chaperone Mechanisms II
Chairperson: Judith Frydman, Stanford University
Rachel Klevit, University of Washington
Clearance Mechanisms
Chairperson: Ivan Dikic, Goethe University Frankfurt, Germany
Daniel Finley, Harvard Medical School
Dan Southworth, University of California, San Francisco
Organellar Proteostasis and Spatial Quality Control
Chairperson: Peter Walter, University of California, San Francisco
Thomas Langer, University of Cologne, Germany
David Ron, University of Cambridge
Correcting Proteostasis in Aging and Disease
Chairperson: Gergely Lukacs, McGill University
Jeff Kelly, The Scripps Research Institute
Веб-сторінка конференції: https://meetings.cshl.edu/meetings.aspx?meet=HEAT&year=20